| 名稱 | PDGFRA D842V/BaF3 | 
| 型號(hào) | CBP73238 | 
| 報(bào)價(jià) | ![]()  | 
								
| 特點(diǎn) | PDGFRA D842V/BaF3,母細(xì)胞:BaF3,凍存條件:90% FBS+10% DMSO | 
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						藥靶細(xì)胞株 > kinase激酶細(xì)胞株  >  CBP73238PDGFRA D842V/BaF3
            
              
					
				
				
						- 詳細(xì)內(nèi)容
 
| CBP73238 | |
| I. Introduction | |
Cell Line Name:  | PDGFRA D842V/BaF3  | 
Host Cell:  | Ba/F3  | 
| Stability: | 16 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) | 
Application:  | Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.  | 
Freeze Medium:  | 90% FBS+10% DMSO  | 
Complete Culture Medium:  | RPMI-1640+10%FBS  | 
Mycoplasma Status:  | Negative  | 
| II.Background | |
PDGFRA D842V lies within the protein kinase domain of the Pdgfra protein (UniProt.org). D842V results in ligand-independent phosphorylation of Pdgfra, activation of downstream signaling, and is transforming in culture (PMID: 22745105, PMID: 23752188, PMID: 29533785, PMID: 30253204) and confers resistance to PDGFRA inhibitors (PMID: 30389923, PMID: 18955458).  | |
| III. Representative Data | |
1.PDGFRA D842V/BaF3 
  | |
2.Sanger of PDGFRA D842V/BaF3 
 Figure 2. PDGFRA D842V/BaF3 D842V  | |
3. Anti-proliferation assay  | |
  Figure 3. CTG Proliferation Assay of BaF3 PDGFRA D842V Cells(C6).  | |










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