| 名稱 | CD27/NFκB-Luc/Jurkat |
| 型號(hào) | CBP74007 |
| 報(bào)價(jià) |  |
| 特點(diǎn) | CD27/NFκB-Luc/Jurkat，凍存條件：90% FBS+10% DMSO |
產(chǎn)品搜索
相關(guān)文章
- VKORC1基因多態(tài)性用藥指導(dǎo)標(biāo)準(zhǔn)品
- 腫瘤細(xì)胞內(nèi)的膠原蛋白有哪些作用？
- 示蹤細(xì)胞在活體成像技術(shù)中的應(yīng)用
- Nectin-4, ADC賽道新星靶點(diǎn)
- HRD檢測(cè)之我見---科佰生物
- 新品發(fā)布【地中海貧血標(biāo)準(zhǔn)品】
- 長期研究使用的腦癌細(xì)胞系或面臨“身份危機(jī)”
- 【產(chǎn)品推介】腫瘤耐藥細(xì)胞株
- 5月是黑色素瘤意識(shí)月，盤點(diǎn)黑色素瘤研究進(jìn)展
- JCI：中山大學(xué)科學(xué)家找到可能*治愈常見白血病的新靶點(diǎn)
聯(lián)系我們
聯(lián)系人：蔣經(jīng)理
電話：4008750250
號(hào)碼：
手機(jī)：18066071954
地址：南京市棲霞區(qū)緯地路9號(hào)
Email： zhangxiangwen@cobioer.com
電話：4008750250
號(hào)碼：
手機(jī)：18066071954
地址：南京市棲霞區(qū)緯地路9號(hào)
Email： zhangxiangwen@cobioer.com
產(chǎn)品展示 / PRODUCTS
藥靶細(xì)胞株 > 腫瘤免疫細(xì)胞株 > CBP74007CD27/NFκB-Luc/Jurkat
- 詳細(xì)內(nèi)容
| CBP74007 | |
| I. Background | |
CD27 is a member of the tumor necrosis factor (TNF) receptor superfamily, which includes the T cell co-stimulatory receptors OX40, 4-1BB and herpesvirus entry mediator (HVEM). CD27 is expressed on various types of T cells, B cells and a subset of natural killer cells. It activates NF-κB and MAPK/JNK signaling upon interaction with its TNF-like ligand, CD70, which is expressed by numerous tumor cells. Adaptor proteins TRAF2 and TRAF5 can also stimulate CD27 signaling. Activation of CD27 leads to lymphoid proliferation, differentiation, apoptosis, and the induction of long-term memory. The CD27/CD70 pathway is a key target for the development of treatments for cancer and inflammatory diseases. | |
| II. Description | |
| Recombinant Jurkat T cell expressing firefly luciferase gene under the control of NF-kB response elements with constitutive expression of human CD27 (also known as Tumor Necrosis Factor Receptor Superfamily Member 7, TNFRSF7, and T14, Genbank Accession #BC012160) | |
| III. Introduction | |
| Host Cell: | Jurkat |
| Expressed gene: | CD27-NFκB-Luciferase |
| Stability: | 32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) |
| Synonym(s): | Tumor Necrosis Factor Receptor Superfamily Member 7, TNFRSF7, T14, cd27 cell line, cd-27, nfkb, nf-kb |
| Freeze Medium: | 90% FBS+10% DMSO |
| Culture Medium: | RPMI-1640+10%FBS+800ug/ml hygromycin+1ug/ml puromycin |
| Mycoplasma Testing: | Negative |
| Storage: | Liquid nitrogen |
| Application(s): | Functional(Report Gene) Assay |
| IV. Description of Host Cell Line | |
| Organism: | Homo sapiens, human |
| Tissue: | Peripheral blood |
| Disease: | Childhood T acute lymphoblastic leukemia |
| Morphology: | Lymphoblast |
| Growth Properties: | Suspension |
| Ⅴ. Representative Data | |
| |
Figure 1. Recombinant Jurkat stably expressing human CD27-NFκB. | |
Figure 2. Detect Luciferase assay by Ultra Luciferase Detection Kit CBPH0001（we strongly suggest to purchase from Cobioer). Jurkat-CD27-NFκB-Luciferase Reporter cells were stimulated by CD70/CHO cells, the S/B was 26.5-fold. |
會(huì)員_a.png)