| 名稱 | EGFR p.747_753LREATSP>S Reference Standard |
| 型號(hào) | CBP10345 |
| 報(bào)價(jià) |  |
| 特點(diǎn) | EGFR p.747_753LREATSP>S Reference Standard |
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電話：4008750250
號(hào)碼：
手機(jī)：18066071954
地址：南京市棲霞區(qū)緯地路9號(hào)
Email： zhangxiangwen@cobioer.com
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基因檢測(cè)標(biāo)準(zhǔn)品 > Mutation > CBP10345EGFR p.747_753LREATSP>S Reference Standard
- 詳細(xì)內(nèi)容
CBP10345 | |
| Gene | EGFR |
| Description | EGFR (HER1), epidermal growth factor receptor, is a tyrosine kinase receptor, which activates RAS/RAF/MEK and PI3K/AKT/mTOR pathways, leading to increased cell proliferation and growth (PMID: 24312144). EGFR activating mutations, amplification, and overexpression are found in a variety of tumor tumors, including non-small cell lung cancer (PMID: 26609494, PMID: 30284706) and colorectal cancer (PMID: 30243897), and the EGFRvIII variant is commonly found in glioblastoma (PMID: 30201736). |
| Technical Data | |
| DNA Change | c.2240_2257del18 TAAGAGAAGCAACATCTC>- |
| AA Change | p.L747_P753LREATSP>S |
| Mutation type | Deletion - In frame |
| Zygosity | Heterozygous |
| Allelic Frequency | 50.00% |
| Transcript | ENST00000275493 |
| Cosmic ID | COSM12370 |
| Chr position(GRCh37) | chr7:55242470_55242487 |
| Buffer | Tris-EDTA |
| Product Information | |
| Intended Use | Research Use Only |
| Unit Size | 1ug |
| Concentration | Download for COA |
| Purofication | Download for COA |
| DNA electrophoresis | Download for COA |
| Sanger sequencing |
|
| Storage | 4℃ |
| Expiry | 36 months from the date of manufacture |
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