| 名稱 | MAP2K1 p.P124S Reference Standard 標(biāo)準(zhǔn)品 |
| 型號(hào) | CBP10305 |
| 報(bào)價(jià) |  |
| 特點(diǎn) | MAP2K1 p.P124S Reference Standard |
產(chǎn)品搜索
相關(guān)文章
- 新型冠狀病毒：用于診斷的假病毒標(biāo)準(zhǔn)品和用于藥物研發(fā)的假病毒模型
- 【靶點(diǎn)模型+診斷質(zhì)控】BTK C481S的藥物開(kāi)發(fā)和診斷
- 【產(chǎn)品推介】CD47&SIRPɑ 細(xì)胞篩選模型
- BTK細(xì)胞篩選模型
- GLP-1R、GCGR、GIPR多靶點(diǎn)激動(dòng)劑與代謝疾病
- IL-11藥物細(xì)胞模型簡(jiǎn)介
- IL27細(xì)胞篩選模型
- 針對(duì)ctDNA的MRD檢測(cè)，你參與了嗎？
- 細(xì)胞因子風(fēng)暴和自身免疫性炎癥治療新靶點(diǎn)GM-CSF
- 強(qiáng)強(qiáng)聯(lián)合！IBM與MIT開(kāi)展腫瘤藥物抗藥性研究
聯(lián)系我們
聯(lián)系人：蔣經(jīng)理
電話：4008750250
號(hào)碼：
手機(jī)：18066071954
地址：南京市棲霞區(qū)緯地路9號(hào)
Email： zhangxiangwen@cobioer.com
電話：4008750250
號(hào)碼：
手機(jī)：18066071954
地址：南京市棲霞區(qū)緯地路9號(hào)
Email： zhangxiangwen@cobioer.com
產(chǎn)品展示 / PRODUCTS
基因檢測(cè)標(biāo)準(zhǔn)品 > Mutation > CBP10305MAP2K1 p.P124S Reference Standard 標(biāo)準(zhǔn)品
- 詳細(xì)內(nèi)容
" _ue_custom_node_="true">
CBP10305 | |
| Format | Genomic DNA |
| Description | MAP2K1 P124S lies within the protein kinase domain of the Map2k1 protein (UniProt.org). The functional effect of P124S is conflicting, as P124S has been reported to confer a gain of function on the Map2k1 protein as demonstrated by increased ERK1/2 phosphorylation, but has similar induction of cell proliferation and viability levels as wild-type Map2k1 (PMID: 29533785), and also confers resistance to Mek and Braf inhibitors in melanoma cells (PMID: 19915144, PMID: 22197931), |
| Technical Data | |
| DNA Change | c.370C>T |
| AA Change | p.P124S |
| Mutation type | Substitution - Missense |
| Zygosity | Heterozygous |
| Allelic Frequency | 50.00% |
| Transcript | ENST00000307102 |
| Cosmic ID | COSM235614 |
| Chr position(GRCh37) | chr15:66729162 |
| Buffer | Tris-EDTA |
| Product Information | |
| Intended Use | Research Use Only |
| Unit Size | 1ug |
| Concentration | Download for COA |
| Purofication | Download for COA |
| DNA electrophoresis | Download for COA |
| Sanger sequencing |
|
| Storage | 4℃ |
| Expiry | 36 months from the date of manufacture |
會(huì)員_a.png)