| 名稱 | PDGF/PDGFRB Effector Reporter Cell |
| 型號(hào) | CBP74316 |
| 報(bào)價(jià) | ![]() |
| 特點(diǎn) | PDGF/PDGFRB Effector Reporter Cell |
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藥靶細(xì)胞株 > 腫瘤免疫細(xì)胞株 > CBP74316PDGF/PDGFRB Effector Reporter Cell
- 詳細(xì)內(nèi)容
| I. Background | |
血小板衍生生長因子(PDGF)是一類重要的生長因子,主要由血小板、內(nèi)皮細(xì)胞和 巨噬細(xì)胞分泌,在細(xì)胞增殖、遷移、分化和血管生成等生物學(xué)過程中發(fā)揮關(guān)鍵作用。它不 僅在正常生理過程中(如傷口愈合和組織修復(fù))起重要作用,還在多種病理過程中(如癌 癥、纖維化和動(dòng)脈粥樣硬化)扮演重要角色。PDGF家族包括PDGF-A、PDGF-B、PDGF C和PDGF-D四種亞型。PDGF通過與其受體(PDGFR)結(jié)合,激活下游信號(hào)通路,調(diào)控細(xì)胞行為。 | |
| II. Description | |
PDGF/PDGFRB Effector Reporter Cell 報(bào)告基因藥靶模型很好的模擬了體內(nèi)PDGFRB的信號(hào)轉(zhuǎn)導(dǎo)過程,原理見下圖所示。
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| III. Introduction | |
| Expressed gene: | PDGFRB |
| Stability: | 32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) |
| Freeze Medium: | 90% FBS+10% DMSO |
| Culture Medium: | DMEM+10%FBS+200 μg/ml Hygromycin B+2 μg/ml Puromycin |
| Mycoplasma Testing: | Negative |
| Storage: | Liquid nitrogen |
| Application(s): | Functional(Report Gene) Assay |
| IV. Representative Data
Figure 3. Dose Response of Recombinant Human PDGF-BB in PDGF/PDGFRB Effector Reporter Cell(C26).
Figure 4. Inhibition of Human PDGF-BB-induced Reporter Activity by PDGFRB Blocking Abs in PDGF/DGFRB Effector Reporter Cell(C26). Inhibition of Human PDGF-BB-induced Reporter Activity by PDGFB Neutralization Ab in PDGF/PDGFRB Effector Reporter Cell(C26). | |








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